4G3E

Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to a 6-alkynylindoline (cmp1)

Summary for 4G3E

• Entry DOI: 10.2210/pdb4g3e/pdb
• Related: 4G3C 4G3D 4G3F 4G3G
• Descriptor: NF-kappa-beta-inducing kinase, SULFATE ION, (2R)-4-[1-(2-amino-5-chloropyrimidin-4-yl)-2,3-dihydro-1H-indol-6-yl]-2-(1,3-thiazol-2-yl)but-3-yn-2-ol, ... (4 entities in total)
• Functional Keywords: non-rd kinase, protein serine/threonine kinase, nf-kappab, structure-based drug design, map3k14, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Mus musculus (mouse)
• Cellular location: Cytoplasm: Q9WUL6
• Total number of polymer chains: 2
• Total formula weight: 78687.31

Authors

Hymowitz, S.G.,de Leon-Boenig, G. (deposition date: 2012-07-13, release date: 2012-08-15, Last modification date: 2024-04-03)

• Primary citation: de Leon-Boenig, G.,Bowman, K.K.,Feng, J.A.,Crawford, T.,Everett, C.,Franke, Y.,Oh, A.,Stanley, M.,Staben, S.T.,Starovasnik, M.A.,Wallweber, H.J.,Wu, J.,Wu, L.C.,Johnson, A.R.,Hymowitz, S.G.; The crystal structure of the catalytic domain of the NF-kappaB inducing kinase reveals a narrow but flexible active site.; Structure, 20:1704-1714, 2012; PubMed: 22921830; DOI: 10.1016/j.str.2012.07.013

Experimental method

X-RAY DIFFRACTION (2.5 Å)