4FS2
Base pairing mechanism of N2,3-ethenoguanine with dCTP by human polymerase iota
Summary for 4FS2
Entry DOI | 10.2210/pdb4fs2/pdb |
Related | 3OSN 3V6H 3V6J 3V6K 4FS1 |
Descriptor | DNA (5'-D(*TP*CP*TP*(EFG)P*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*(DOC))-3'), DNA polymerase iota, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | human dna polymerase iota, dna polymerase, dna replication, lesion bypass, 2'-fluoro arabinose, n2, 3-ethenoguanine, dttp, template, transferase-dna complex, transferase/dna |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: Q9UNA4 |
Total number of polymer chains | 3 |
Total formula weight | 58659.54 |
Authors | Zhao, L. (deposition date: 2012-06-26, release date: 2012-08-29, Last modification date: 2024-02-28) |
Primary citation | Zhao, L.,Pence, M.G.,Christov, P.P.,Wawrzak, Z.,Choi, J.Y.,Rizzo, C.J.,Egli, M.,Guengerich, F.P. Basis of Miscoding of the DNA Adduct N2,3-Ethenoguanine by Human Y-family DNA Polymerases. J.Biol.Chem., 287:35516-35526, 2012 Cited by PubMed: 22910910DOI: 10.1074/jbc.M112.403253 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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