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4FBW

Crystal structure of an unfused Mre11-Nbs1 complex with two manganese ions per active site

Summary for 4FBW
Entry DOI10.2210/pdb4fbw/pdb
Related4FCX 4fbk 4fbq
DescriptorDNA repair protein rad32, DNA repair and telomere maintenance protein nbs1, MANGANESE (II) ION, ... (4 entities in total)
Functional Keywordsdna double-strand break repair, nuclease, hydrolase, hydrolase-protein binding complex, hydrolase/protein binding
Biological sourceSchizosaccharomyces pombe (Fission yeast)
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Cellular locationNucleus : Q09683 O43070
Total number of polymer chains4
Total formula weight108937.83
Authors
Schiller, C.B.,Lammens, K.,Hopfner, K.P. (deposition date: 2012-05-23, release date: 2012-06-20, Last modification date: 2024-02-28)
Primary citationSchiller, C.B.,Lammens, K.,Guerini, I.,Coordes, B.,Feldmann, H.,Schlauderer, F.,Mockel, C.,Schele, A.,Strasser, K.,Jackson, S.P.,Hopfner, K.P.
Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.
Nat.Struct.Mol.Biol., 19:693-700, 2012
Cited by
PubMed: 22705791
DOI: 10.1038/nsmb.2323
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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