4FBQ
Crystal structure of a covalently fused Nbs1-Mre11 complex with two manganese ions per active site
Summary for 4FBQ
Entry DOI | 10.2210/pdb4fbq/pdb |
Related | 4FBW 4FCX 4fbk |
Descriptor | DNA repair and telomere maintenance protein nbs1,DNA repair protein rad32 CHIMERIC PROTEIN, MANGANESE (II) ION (3 entities in total) |
Functional Keywords | dna double-strand break repair, nuclease, hydrolase, protein binding |
Biological source | Schizosaccharomyces pombe (Fission yeast) More |
Cellular location | Nucleus : Q09683 |
Total number of polymer chains | 2 |
Total formula weight | 106923.58 |
Authors | Schiller, C.B.,Lammens, K.,Hopfner, K.P. (deposition date: 2012-05-23, release date: 2012-06-20, Last modification date: 2024-02-28) |
Primary citation | Schiller, C.B.,Lammens, K.,Guerini, I.,Coordes, B.,Feldmann, H.,Schlauderer, F.,Mockel, C.,Schele, A.,Strasser, K.,Jackson, S.P.,Hopfner, K.P. Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling. Nat.Struct.Mol.Biol., 19:693-700, 2012 Cited by PubMed: 22705791DOI: 10.1038/nsmb.2323 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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