4E5A

The W197A mutant of p38a MAP kinase

Summary for 4E5A

Entry DOI	10.2210/pdb4e5a/pdb
Related	1P38 2NPQ 4E5B 4E6A 4E6C 4E8A
Descriptor	Mitogen-activated protein kinase 14 (2 entities in total)
Functional Keywords	map kinase, p38, signal trunsduction, alternative activation modes, kinase tompoly, kinase, phosphorylaiton, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : Q16539
Total number of polymer chains	1
Total formula weight	41228.07
Authors	Livnah, O.,Tzarum, N.,Eisenberg-Domovich, Y. (deposition date: 2012-03-14, release date: 2012-10-31, Last modification date: 2024-02-28)
Primary citation	Tzarum, N.,Eisenberg-Domovich, Y.,Gills, J.J.,Dennis, P.A.,Livnah, O. Lipid Molecules Induce p38 alpha Activation via a Novel Molecular Switch. J.Mol.Biol., 424:339-353, 2012 Cited by PubMed: 23079240 DOI: 10.1016/j.jmb.2012.10.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.87 Å)

Structure validation