4E6C

p38a-perifosine Complex

Summary for 4E6C

Entry DOI	10.2210/pdb4e6c/pdb
Related	1P38 2NPQ 4E5A 4E5B 4E6A 4E8A
Descriptor	Mitogen-activated protein kinase 14, (1,1-dimethylpiperidin-1-ium-4-yl) octadecyl hydrogen phosphate (3 entities in total)
Functional Keywords	map kinase, p38, signal transduction, alternative activation modes, lipid binding site, pia, perifosine, kinase fold, kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : Q16539
Total number of polymer chains	1
Total formula weight	41805.86
Authors	Livnah, O.,Tzarum, N.,Eisenberg-Domovich, Y. (deposition date: 2012-03-15, release date: 2012-10-31, Last modification date: 2024-02-28)
Primary citation	Tzarum, N.,Eisenberg-Domovich, Y.,Gills, J.J.,Dennis, P.A.,Livnah, O. Lipid Molecules Induce p38 alpha Activation via a Novel Molecular Switch. J.Mol.Biol., 424:339-353, 2012 Cited by PubMed: 23079240 DOI: 10.1016/j.jmb.2012.10.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.39 Å)

Structure validation