4D9R

Inhibiting Alternative Pathway Complement Activation by Targeting the Exosite on Factor D

Summary for 4D9R

• Entry DOI: 10.2210/pdb4d9r/pdb
• Related: 4D9Q
• Descriptor: Complement factor D, Fab light chain, Fab heavy chain, ... (5 entities in total)
• Functional Keywords: factor d, complement, antibody, exosite, fab, chymotrypsin, protease, hydrolase-immune system complex, hydrolase/immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P00746 P01834 P01857
• Total number of polymer chains: 6
• Total formula weight: 141799.75

Authors

Murray, J.M.,Wiesmann, C. (deposition date: 2012-01-11, release date: 2012-02-22, Last modification date: 2023-09-13)

• Primary citation: Katschke, K.J.,Wu, P.,Ganesan, R.,Kelley, R.F.,Mathieu, M.A.,Hass, P.E.,Murray, J.,Kirchhofer, D.,Wiesmann, C.,van Lookeren Campagne, M.; Inhibiting alternative pathway complement activation by targeting the factor d exosite.; J.Biol.Chem., 287:12886-12892, 2012; PubMed: 22362762; DOI: 10.1074/jbc.M112.345082

Experimental method

X-RAY DIFFRACTION (2.42 Å)