4D9R

Inhibiting Alternative Pathway Complement Activation by Targeting the Exosite on Factor D

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Complement factor D	polymer	228	24438.8	2	UniProt (P00746) Pfam (PF00089) In PDB	Homo sapiens (human)	Adipsin, C3 convertase activator, Properdin factor D
2	L, D	Fab light chain	polymer	214	23235.7	2	UniProt (P01834) Pfam (PF07654) In PDB	Homo sapiens (human)
3	H, E	Fab heavy chain	polymer	218	23189.9	2	UniProt (P01857) Pfam (PF07654) In PDB	Homo sapiens (human)
4	D	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
5		water	water		18.0	349	Chemie (HOH)

Sequence modifications

L, D: 1 - 104 (PDB: 4D9R)
L, D: 109 - 214 (UniProt: P01834)

PDB	External Database	Details
Glu 105	-	linker
Ile 106	-	linker
Lys 107	-	linker
Arg 108	-	linker

H, E: 1 - 116 (PDB: 4D9R)
H, E: 122 - 224 (UniProt: P01857)

PDB	External Database	Details
Val 117	-	linker
Thr 118	-	linker
Val 119	-	linker
Ser 120	-	linker
Ser 121	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	141728.8
Non-Polymers*	Number of molecules	2
	Total formula weight	70.9
All*	Total formula weight	141799.7

*Water molecules are not included.