4C78

Complex of human Sirt3 with Bromo-Resveratrol and ACS2 peptide

Summary for 4C78

• Entry DOI: 10.2210/pdb4c78/pdb
• Related: 4C7B
• Descriptor: NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL, ACETYL-COENZYME A SYNTHETASE 2-LIKE, MITOCHONDRIAL, 5-[(E)-2-(4-bromophenyl)ethenyl]benzene-1,3-diol, ... (5 entities in total)
• Functional Keywords: hydrolase, sirtuin, inhibitor, activation, resveratrol, sirt1, metabolic sensor, metabolism, aging
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Mitochondrion matrix: Q9NTG7 Q9NUB1
• Total number of polymer chains: 2
• Total formula weight: 33089.29

Authors

Nguyen, G.T.T.,Gertz, M.,Weyand, M.,Steegborn, C. (deposition date: 2013-09-19, release date: 2013-11-20, Last modification date: 2023-12-20)

• Primary citation: Nguyen, G.T.T.,Gertz, M.,Steegborn, C.; Crystal Structures of Sirt3 Complexes with 4'-Bromo-Resveratrol Reveal Binding Sites and Inhibition Mechanism.; Chem.Biol., 20:1375-, 2013; PubMed: 24211137; DOI: 10.1016/J.CHEMBIOL.2013.09.019

Experimental method

X-RAY DIFFRACTION (2 Å)