4C7B
Complex of human Sirt3 with Bromo-Resveratrol and Fluor-De-Lys peptide
Summary for 4C7B
| Entry DOI | 10.2210/pdb4c7b/pdb |
| Related | 4C78 |
| Descriptor | NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL, PEPTIDE, ZINC ION, ... (7 entities in total) |
| Functional Keywords | hydrolase-peptide complex, hydrolase, sirtuin, inhibitor, activation, resveratrol, sirt1, metabolic sensor, metabolism, aging, hydrolase/peptide |
| Biological source | HOMO SAPIENS (HUMAN) More |
| Cellular location | Mitochondrion matrix : Q9NTG7 |
| Total number of polymer chains | 2 |
| Total formula weight | 32890.00 |
| Authors | Nguyen, G.T.T.,Gertz, M.,Weyand, M.,Steegborn, C. (deposition date: 2013-09-20, release date: 2013-11-20, Last modification date: 2023-12-20) |
| Primary citation | Nguyen, G.T.T.,Gertz, M.,Steegborn, C. Crystal Structures of Sirt3 Complexes with 4'-Bromo-Resveratrol Reveal Binding Sites and Inhibition Mechanism. Chem.Biol., 20:1375-, 2013 Cited by PubMed: 24211137DOI: 10.1016/J.CHEMBIOL.2013.09.019 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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