4C2B

Crystal Structure of High-Affinity von Willebrand Factor A1 domain with Disulfide Mutation in Complex with High Affinity GPIb alpha

Summary for 4C2B

• Entry DOI: 10.2210/pdb4c2b/pdb
• Related: 4C29 4C2A
• Descriptor: VON WILLEBRAND FACTOR, PLATELET GLYCOPROTEIN IB ALPHA CHAIN, SULFATE ION, ... (6 entities in total)
• Functional Keywords: blood clotting
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Secreted: P04275; Membrane; Single-pass type I membrane protein: P07359
• Total number of polymer chains: 8
• Total formula weight: 230057.11

Authors

Blenner, M.A.,Dong, X.,Springer, T.A. (deposition date: 2013-08-16, release date: 2014-01-08, Last modification date: 2023-12-20)

• Primary citation: Blenner, M.A.,Dong, X.,Springer, T.A.; Towards the Structural Basis of Regulation of Von Willebrand Factor Binding to Glycoprotein Ib; J.Biol.Chem., 289:5565-, 2014; PubMed: 24391089; DOI: 10.1074/JBC.M113.511220

Experimental method

X-RAY DIFFRACTION (2.8 Å)