4C2A

Crystal Structure of High-Affinity von Willebrand Factor A1 domain with R1306Q and I1309V Mutations in Complex with High Affinity GPIb alpha

Summary for 4C2A

Entry DOI	10.2210/pdb4c2a/pdb
Related	4C29 4C2B
Descriptor	VON WILLEBRAND FACTOR, PLATELET GLYCOPROTEIN IB ALPHA CHAIN, CACODYLATE ION, ... (7 entities in total)
Functional Keywords	blood clotting, cell adhesion, a1, gpibalpha
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Secreted : P04275 Membrane; Single-pass type I membrane protein: P07359
Total number of polymer chains	2
Total formula weight	57503.90
Authors	Blenner, M.A.,Dong, X.,Springer, T.A. (deposition date: 2013-08-16, release date: 2014-01-08, Last modification date: 2023-12-20)
Primary citation	Blenner, M.A.,Dong, X.,Springer, T.A. Towards the Structural Basis of Regulation of Von Willebrand Factor Binding to Glycoprotein Ib J.Biol.Chem., 289:5565-, 2014 Cited by PubMed: 24391089 DOI: 10.1074/JBC.M113.511220 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.081 Å)

Structure validation