4BL3

Crystal structure of PBP2a clinical mutant N146K from MRSA

Summary for 4BL3

Entry DOI	10.2210/pdb4bl3/pdb
Related	4BL2
Descriptor	PENICILLIN BINDING PROTEIN 2 PRIME, CADMIUM ION, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	hydrolase, mrsa, allosteric site, b-lactam antibiotics
Biological source	STAPHYLOCOCCUS AUREUS
Total number of polymer chains	2
Total formula weight	147718.44
Authors	Otero, L.H.,Rojas-Altuve, A.,Carrasco-Lopez, C.,Hermoso, J.A. (deposition date: 2013-04-30, release date: 2014-05-21, Last modification date: 2023-12-20)
Primary citation	Fishovitz, J.,Rojas-Altuve, A.,Otero, L.H.,Dawley, M.,Carrasco-Lopez, C.,Chang, M.,Hermoso, J.A.,Mobashery, S. Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics. J.Am.Chem.Soc., 136:9814-, 2014 Cited by PubMed: 24955778 DOI: 10.1021/JA5030657 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation