4AW5

Complex of the EphB4 kinase domain with an oxindole inhibitor

Summary for 4AW5

• Entry DOI: 10.2210/pdb4aw5/pdb
• Related: 2BBA 2VWU 2VWV 2VWW 2VWX 2VWY 2VWZ 2VX0 2VX1 2X9F 2XVD
• Descriptor: EPHRIN TYPE-B RECEPTOR 4, (3Z)-5-[(1-ethylpiperidin-4-yl)amino]-3-[(5-methoxy-1H-benzimidazol-2-yl)(phenyl)methylidene]-1,3-dihydro-2H-indol-2-one (3 entities in total)
• Functional Keywords: transferase
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cell membrane; Single-pass type I membrane protein: P54760
• Total number of polymer chains: 1
• Total formula weight: 33390.37

Authors

Till, J.H.,Stout, T.J. (deposition date: 2012-05-31, release date: 2012-08-01)

• Primary citation: Kim, M.H.,Tsuhako, A.L.,Co, E.W.,Aftab, D.T.,Bentzien, F.,Chen, J.,Cheng, W.,Engst, S.,Goon, L.,Klein, R.R.,Le, D.T.,Mac, M.,Parks, J.J.,Qian, F.,Rodriquez, M.,Stout, T.J.,Till, J.H.,Won, K.A.,Wu, X.,Michael Yakes, F.,Yu, P.,Zhang, W.,Zhao, Y.,Lamb, P.,Nuss, J.M.,Xu, W.; The Design, Synthesis, and Biological Evaluation of Potent Receptor Tyrosine Kinase Inhibitors.; Bioorg.Med.Chem.Lett., 22:4979-, 2012; PubMed: 22765894; DOI: 10.1016/J.BMCL.2012.06.029

Experimental method

X-RAY DIFFRACTION (2.33 Å)