2VX0

ephB4 kinase domain inhibitor complex

Summary for 2VX0

Entry DOI	10.2210/pdb2vx0/pdb
Related	2BBA 2VWU 2VWV 2VWW 2VWX 2VWY 2VWZ 2VX1
Descriptor	EPHRIN TYPE-B RECEPTOR 4, N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3-MORPHOLIN-4-YLPHENYL)PYRIMIDINE-2,4-DIAMINE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	mutant, membrane, transferase, atp-binding, polymorphism, glycoprotein, transmembrane, phosphoprotein, unphosphorylated, nucleotide-binding
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	34433.60
Authors	Read, J.,Brassington, C.A.,Green, I.,McCall, E.J.,Valentine, A.L.,Barratt, D.,Leach, A.G.,Kettle, J.G. (deposition date: 2008-06-30, release date: 2008-10-28, Last modification date: 2023-12-13)
Primary citation	Bardelle, C.,Cross, D.,Davenport, S.,Kettle, J.G.,Ko, E.J.,Leach, A.G.,Mortlock, A.,Read, J.,Roberts, N.J.,Robins, P.,Williams, E.J. Inhibitors of the Tyrosine Kinase Ephb4. Part 1: Structure-Based Design and Optimization of a Series of 2,4-Bis-Anilinopyrimidines. Bioorg.Med.Chem.Lett., 18:2776-, 2008 Cited by PubMed: 18434142 DOI: 10.1016/J.BMCL.2008.04.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation