4APN

Structure of TR from Leishmania infantum in complex with a diarylpirrole-based inhibitor

Summary for 4APN

Entry DOI	10.2210/pdb4apn/pdb
Related	2JK6 2W0H 2X50 2YAU 4ADW
Descriptor	TRYPANOTHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywords	oxidoreductase, trypanosomatids
Biological source	LEISHMANIA INFANTUM
Total number of polymer chains	2
Total formula weight	115267.63
Authors	Baiocco, P.,Ilari, A.,Colotti, G.,Biava, M. (deposition date: 2012-04-04, release date: 2013-04-17, Last modification date: 2023-12-20)
Primary citation	Baiocco, P.,Poce, G.,Alfonso, S.,Cocozza, M.,Porretta, G.C.,Colotti, G.,Biava, M.,Moraca, F.,Botta, M.,Yardley, V.,Fiorillo, A.,Lantella, A.,Malatesta, F.,Ilari, A. Inhibition of Leishmania Infantum Trypanothione Reductase by Azole-Based Compounds: A Comparative Analysis with its Physiological Substrate by X-Ray Crystallography. Chemmedchem, 8:1175-, 2013 Cited by PubMed: 23733388 DOI: 10.1002/CMDC.201300176 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation