4ADW
CRYSTAL STRUCTURE OF LEISHMANIA INFANTUM TRYPANOTHIONE REDUCTASE IN COMPLEX WITH NADPH AND TRYPANOTHIONE
Summary for 4ADW
Entry DOI | 10.2210/pdb4adw/pdb |
Related | 2JK6 2W0H 2X50 2YAU |
Descriptor | TRYPANOTHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total) |
Functional Keywords | oxidoreductase, inhibition mechanism |
Biological source | LEISHMANIA INFANTUM |
Total number of polymer chains | 2 |
Total formula weight | 115024.76 |
Authors | Baiocco, P.,Ilari, A.,Colotti, G.,Malatesta, F.,Fiorillo, A. (deposition date: 2012-01-04, release date: 2013-01-16, Last modification date: 2023-12-20) |
Primary citation | Baiocco, P.,Poce, G.,Alfonso, S.,Cocozza, M.,Porretta, G.C.,Colotti, G.,Biava, M.,Moraca, F.,Botta, M.,Yardley, V.,Fiorillo, A.,Lantella, A.,Malatesta, F.,Ilari, A. Inhibition of Leishmania Infantum Trypanothione Reductase by Azole-Based Compounds: A Comparative Analysis with its Physiological Substrate by X-Ray Crystallography. Chemmedchem, 8:1175-, 2013 Cited by PubMed: 23733388DOI: 10.1002/CMDC.201300176 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.61 Å) |
Structure validation
Download full validation report