3ZVV

Fragment Bound to PI3Kinase gamma

Summary for 3ZVV

• Entry DOI: 10.2210/pdb3zvv/pdb
• Related: 1E8Y 1E8Z 1HE8 2A4Z 2A5U 2CHW 2CHX 2CHZ 2V4L
• Descriptor: PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM, 5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-amine (3 entities in total)
• Functional Keywords: transferase, pi3 kinase gamma
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm : P48736
• Total number of polymer chains: 1
• Total formula weight: 110889.29

Authors

Hughes, S.J.,Milan, D.S.,Kilty, I.C.,Lewthwaite, R.A.,Mathias, J.P.,O'Reilly, M.A.,Phelan, A.,Baldock, D.A.,Brown, D.G. (deposition date: 2011-07-27, release date: 2011-09-28, Last modification date: 2018-02-07)

• Primary citation: Hughes, S.J.,Millan, D.S.,Kilty, I.C.,Lewthwaite, R.A.,Mathias, J.P.,O'Reilly, M.A.,Pannifer, A.,Phelan, A.,Stuhmeier, F.,Baldock, D.A.,Brown, D.G.; Fragment based discovery of a novel and selective PI3 kinase inhibitor.; Bioorg. Med. Chem. Lett., 21:6586-6590, 2011; PubMed: 21925880; DOI: 10.1016/j.bmcl.2011.07.117

Experimental method

X-RAY DIFFRACTION (2.5 Å)