2V4L

complex of human phosphoinositide 3-kinase catalytic subunit gamma (p110 gamma) with PIK-284

Summary for 2V4L

Entry DOI	10.2210/pdb2v4l/pdb
Related	1E8Y 1E8Z 1HE8 2A4Z 2A5U 2CHW 2CHX 2CHZ
Descriptor	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM, 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL (3 entities in total)
Functional Keywords	transferase, lipid kinase, phosphoinositide, pyrazolopyrimidine, s1, kinase, pik-284, 3-kinase, inhibitor, signaling
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm: P48736
Total number of polymer chains	1
Total formula weight	111025.47
Authors	Apsel, B.,Gonzalez, B.,Blair, J.A.,Nazif, T.M.,Feldman, M.E.,Williams, R.L.,Shokat, K.M.,Knight, Z.A. (deposition date: 2008-09-25, release date: 2008-10-14, Last modification date: 2023-12-13)
Primary citation	Apsel, B.,Blair, J.A.,Gonzalez, B.,Nazif, T.M.,Feldman, M.E.,Aizenstein, B.,Hoffman, R.,Williams, R.L.,Shokat, K.M.,Knight, Z.A. Targeted Polypharmacology: Discovery of Dual Inhibitors of Tyrosine and Phosphoinositide Kinases. Nat.Chem.Biol., 4:691-, 2008 Cited by PubMed: 18849971 DOI: 10.1038/NCHEMBIO.117 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation