3ZRC

pVHL54-213-EloB-EloC complex (4R)-4-HYDROXY-1-[(3-METHYLISOXAZOL-5-YL)ACETYL]-N-[4-(1,3-OXAZOL-5-YL)BENZYL]-L-PROLINAMIDE bound

Summary for 3ZRC

Entry DOI	10.2210/pdb3zrc/pdb
Related	1LM8 1LQB 1VCB 2C9W 2IZV 2XAI 3ZRF 3ZTC 3ZTD 3ZUN
Descriptor	TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1, VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR, ... (5 entities in total)
Functional Keywords	transcription, tumour supressor protein, chronic aneamia tre e3 treatment, e3 ubiquitin ligase
Biological source	HOMO SAPIENS More
Cellular location	Nucleus (Probable): Q15370 Q15369 Isoform 1: Cytoplasm. Isoform 3: Cytoplasm: P40337
Total number of polymer chains	12
Total formula weight	173493.03
Authors	Van Molle, I.,Buckley, D.L.,Crews, C.M.,Ciulli, A. (deposition date: 2011-06-15, release date: 2012-03-07, Last modification date: 2023-12-20)
Primary citation	Buckley, D.L.,Van Molle, I.,Gareiss, P.C.,Tae, H.S.,Michel, J.,Noblin, D.J.,Jorgensen, W.L.,Ciulli, A.,Crews, C.M. Targeting the Von Hippel-Lindau E3 Ubiquitin Ligase Using Small Molecules to Disrupt the Vhl/Hif-1Alpha Interaction J.Am.Chem.Soc., 134:4465-, 2012 Cited by PubMed: 22369643 DOI: 10.1021/JA209924V PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation