1VCB
THE VHL-ELONGINC-ELONGINB STRUCTURE
Summary for 1VCB
Entry DOI | 10.2210/pdb1vcb/pdb |
Descriptor | PROTEIN (ELONGIN B), PROTEIN (ELONGIN C), PROTEIN (VHL), ... (4 entities in total) |
Functional Keywords | tumor suppressor, cancer, ubiquitin, beta sandwich, transcription, transcriptional elongation |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus (Probable): Q15370 Q15369 Isoform 1: Cytoplasm. Isoform 3: Cytoplasm: P40337 |
Total number of polymer chains | 12 |
Total formula weight | 176764.31 |
Authors | Stebbins, C.E.,Kaelin, W.G.,Pavletich, N.P. (deposition date: 1999-03-13, release date: 1999-04-21, Last modification date: 2023-12-27) |
Primary citation | Stebbins, C.E.,Kaelin Jr., W.G.,Pavletich, N.P. Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function. Science, 284:455-461, 1999 Cited by PubMed: 10205047DOI: 10.1126/science.284.5413.455 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
Download full validation report