3ZNR

HDAC7 bound with inhibitor TMP269

Summary for 3ZNR

• Entry DOI: 10.2210/pdb3znr/pdb
• Related: 3ZNS
• Descriptor: HISTONE DEACETYLASE 7, ZINC ION, POTASSIUM ION, ... (5 entities in total)
• Functional Keywords: hydrolase, class iia hdacs, tfmo
• Biological source: HOMO SAPIENS
• Cellular location: Nucleus: Q8WUI4
• Total number of polymer chains: 3
• Total formula weight: 137696.58

Authors

Lobera, m.,madauss, k.,pohlhaus, d.,trump, r.,nolan, m. (deposition date: 2013-02-15, release date: 2013-03-27, Last modification date: 2013-05-01)

• Primary citation: Lobera, M.,Madauss, K.P.,Pohlhaus, D.T.,Wright, Q.G.,Trocha, M.,Schmidt, D.R.,Baloglu, E.,Trump, R.P.,Head, M.S.,Hofmann, G.A.,Murray-Thompson, M.,Schwartz, B.,Chakravorty, S.,Wu, Z.,Mander, P.K.,Kruidenier, L.,Reid, R.A.,Burkhart, W.,Turunen, B.J.,Rong, J.X.,Wagner, C.,Moyer, M.B.,Wells, C.,Hong, X.,Moore, J.T.,Williams, J.D.,Soler, D.,Ghosh, S.,Nolan, M.A.; Selective Class Iia Histone Deacetylase Inhibition Via a Non-Chelating Zinc Binding Group; Nat.Chem.Biol., 9:319-, 2013; PubMed: 23524983; DOI: 10.1038/NCHEMBIO.1223

Experimental method

X-RAY DIFFRACTION (2.4 Å)