3ZG5

Crystal structure of PBP2a from MRSA in complex with peptidoglycan analogue at allosteric

Summary for 3ZG5

Entry DOI	10.2210/pdb3zg5/pdb
Related	3ZFZ 3ZG0 3ZH3 3ZH4 3ZHG
Descriptor	Penicillin binding protein 2 prime, PEPTIDOGLYCAN ANALOGUE, CADMIUM ION, ... (6 entities in total)
Functional Keywords	hydrolase, penicillin binding proteins, allosteric site, b- lactam antibiotics
Biological source	Staphylococcus aureus subsp. aureus Mu50 More
Total number of polymer chains	4
Total formula weight	148758.45
Authors	Otero, L.H.,Rojas-Altuve, A.,Hermoso, J.A. (deposition date: 2012-12-14, release date: 2013-10-09, Last modification date: 2024-02-07)
Primary citation	Otero, L.H.,Rojas-Altuve, A.,Llarrull, L.I.,Carrasco-Lopez, C.,Kumarasiri, M.,Lastochkin, E.,Fishovitz, J.,Dawley, M.,Hesek, D.,Lee, M.,Johnson, J.W.,Fisher, J.F.,Chang, M.,Mobashery, S.,Hermoso, J.A. How Allosteric Control of Staphylococcus Aureus Penicillin Binding Protein 2A Enables Methicillin Resistance and Physiological Function Proc.Natl.Acad.Sci.USA, 110:16808-, 2013 Cited by PubMed: 24085846 DOI: 10.1073/PNAS.1300118110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation