3ZG0
Crystal structure of ceftaroline acyl-PBP2a from MRSA with non- covalently bound ceftaroline and muramic acid at allosteric site obtained by cocrystallization
Summary for 3ZG0
| Entry DOI | 10.2210/pdb3zg0/pdb |
| Related | 3ZFZ 3ZG5 |
| Descriptor | PENICILLIN BINDING PROTEIN 2 PRIME, Ceftaroline, bound form, CADMIUM ION, ... (7 entities in total) |
| Functional Keywords | hydrolase, mrsa, allosteric site, b-lactam antibiotics |
| Biological source | STAPHYLOCOCCUS AUREUS SUBSP. AUREUS MU50 |
| Total number of polymer chains | 2 |
| Total formula weight | 150543.76 |
| Authors | Otero, L.H.,Rojas-Altuve, A.,Hermoso, J.A. (deposition date: 2012-12-13, release date: 2013-10-09, Last modification date: 2023-12-20) |
| Primary citation | Otero, L.H.,Rojas-Altuve, A.,Llarrull, L.I.,Carrasco-Lopez, C.,Kumarasiri, M.,Lastochkin, E.,Fishovitz, J.,Dawley, M.,Hesek, D.,Lee, M.,Johnson, J.W.,Fisher, J.F.,Chang, M.,Mobashery, S.,Hermoso, J.A. How Allosteric Control of Staphylococcus Aureus Penicillin Binding Protein 2A Enables Methicillin Resistance and Physiological Function Proc.Natl.Acad.Sci.USA, 110:16808-, 2013 Cited by PubMed: 24085846DOI: 10.1073/PNAS.1300118110 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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