3W0U

human Glyoxalase I with an N-hydroxypyridone inhibitor

Summary for 3W0U

• Entry DOI: 10.2210/pdb3w0u/pdb
• Related: 3VW9 3W0T
• Descriptor: Lactoylglutathione lyase, ZINC ION, N-[3-(1-Hydroxy-6-oxo-4-phenyl-1,6-dihydro-pyridin-2-yl)-5-methanesulfonylamino-phenyl]-methanesulfonamide, ... (4 entities in total)
• Functional Keywords: glyoxalase, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 43201.80

Authors

Fukami, T.A.,Irie, M.,Matsuura, T. (deposition date: 2012-11-02, release date: 2013-11-06, Last modification date: 2023-11-08)

• Primary citation: Koyano, H.,Aoki, T.,Yamamoto, S.,Kobayashi, T.,Miura, T.,Ohara, K.,Fukami, T.A.,Irie, M.,Sakamoto, H.; N-Hydroxypyridone-based glyoxalase I inhibitors mimicking binding interactions of the substrate; to be published,

Experimental method

X-RAY DIFFRACTION (1.7 Å)