3VW9
Human Glyoxalase I with an N-hydroxypyridone inhibitor
Summary for 3VW9
| Entry DOI | 10.2210/pdb3vw9/pdb |
| Descriptor | Lactoylglutathione lyase, ZINC ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (5 entities in total) |
| Functional Keywords | glyoxalase, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 43291.94 |
| Authors | Fukami, T.A.,Irie, M.,Matsuura, T. (deposition date: 2012-08-10, release date: 2012-12-12, Last modification date: 2023-11-08) |
| Primary citation | Chiba, T.,Ohwada, J.,Sakamoto, H.,Kobayashi, T.,Fukami, T.A.,Irie, M.,Miura, T.,Ohara, K.,Koyano, H. Design and evaluation of azaindole-substituted N-hydroxypyridones as glyoxalase I inhibitors Bioorg.Med.Chem.Lett., 22:7486-7489, 2012 Cited by PubMed: 23122816DOI: 10.1016/j.bmcl.2012.10.045 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.47 Å) |
Structure validation
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