3VZD
Crystal structure of Sphingosine Kinase 1 with inhibitor and ADP
Summary for 3VZD
Entry DOI | 10.2210/pdb3vzd/pdb |
Related | 3VZB 3VZC |
Descriptor | Sphingosine kinase 1, 4-{[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino}phenol, PYROPHOSPHATE 2-, ... (7 entities in total) |
Functional Keywords | lipid kinase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | homo sapiens |
Cellular location | Cytoplasm: Q9NYA1 |
Total number of polymer chains | 6 |
Total formula weight | 242833.90 |
Authors | Min, X.,Walker, N.P.,Wang, Z. (deposition date: 2012-10-11, release date: 2013-05-01, Last modification date: 2024-03-20) |
Primary citation | Wang, Z.,Min, X.,Xiao, S.H.,Johnstone, S.,Romanow, W.,Meininger, D.,Xu, H.,Liu, J.,Dai, J.,An, S.,Thibault, S.,Walker, N. Molecular basis of sphingosine kinase 1 substrate recognition and catalysis. Structure, 21:798-809, 2013 Cited by PubMed: 23602659DOI: 10.1016/j.str.2013.02.025 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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