3TPX
Crystal structure of human MDM2 in complex with a trifluoromethylated D-peptide inhibitor
Summary for 3TPX
Entry DOI | 10.2210/pdb3tpx/pdb |
Related | 3EQS 3IUX 3IWY 3LNJ 3LNZ |
Related PRD ID | PRD_000995 |
Descriptor | E3 ubiquitin-protein ligase Mdm2, D-peptide inhibitor DPMI-delta, SULFATE ION, ... (6 entities in total) |
Functional Keywords | ligase-ligase inhibitor complex, mdm2-d-peptide inhibitor complex, p53-binding domain of mdm2-d-peptide inhibitor complex, ligase/ligase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus, nucleoplasm: Q00987 |
Total number of polymer chains | 6 |
Total formula weight | 35578.48 |
Authors | Wu, X.,Pazgier, M. (deposition date: 2011-09-08, release date: 2012-06-20, Last modification date: 2023-12-06) |
Primary citation | Zhan, C.,Zhao, L.,Wei, X.,Wu, X.,Chen, X.,Yuan, W.,Lu, W.Y.,Pazgier, M.,Lu, W. An Ultrahigh Affinity d-Peptide Antagonist Of MDM2. J.Med.Chem., 55:6237-6241, 2012 Cited by PubMed: 22694121DOI: 10.1021/jm3005465 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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