3IUX

Crystal structure of human MDM2 in complex with a potent miniature protein inhibitor (18-residues)

Summary for 3IUX

Entry DOI	10.2210/pdb3iux/pdb
Related	1T4E 1YCR 3EQY 3IVJ
Descriptor	E3 ubiquitin-protein ligase Mdm2, miniature protein inhibitor, ACETATE ION, ... (5 entities in total)
Functional Keywords	mdm2, p53 binding domain, peptide activator of p53, host-virus interaction, ligase, metal-binding, nucleus, phosphoprotein, proto-oncogene, ubl conjugation pathway, zinc-finger
Cellular location	Nucleus, nucleoplasm: Q00987
Total number of polymer chains	4
Total formula weight	24806.53
Authors	Pazgier, M.,Lu, W. (deposition date: 2009-08-31, release date: 2009-10-27, Last modification date: 2023-09-06)
Primary citation	Li, C.,Pazgier, M.,Liu, M.,Lu, W.Y.,Lu, W. Apamin as a template for structure-based rational design of potent peptide activators of p53. Angew.Chem.Int.Ed.Engl., 48:8712-8715, 2009 Cited by PubMed: 19827079 DOI: 10.1002/anie.200904550 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation