3TI1
CDK2 in complex with SUNITINIB
Summary for 3TI1
Entry DOI | 10.2210/pdb3ti1/pdb |
Related | 3TIY 3TIZ |
Descriptor | Cyclin-dependent kinase 2, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | protein kinase, allosteric ligand, sunitinib, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton, centrosome: P24941 |
Total number of polymer chains | 1 |
Total formula weight | 34871.51 |
Authors | Alam, R.,Schonbrunn, E. (deposition date: 2011-08-19, release date: 2012-08-22, Last modification date: 2023-09-13) |
Primary citation | Martin, M.P.,Alam, R.,Betzi, S.,Ingles, D.J.,Zhu, J.Y.,Schonbrunn, E. A Novel Approach to the Discovery of Small-Molecule Ligands of CDK2. Chembiochem, 13:2128-2136, 2012 Cited by PubMed: 22893598DOI: 10.1002/cbic.201200316 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.99 Å) |
Structure validation
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