3S9Y

Crystal Structure of P. falciparum orotidine 5'-monophosphate decarboxylase complexed with 5-fluoro-6-amino-UMP in space group P21, produced from 5-fluoro-6-azido-UMP

Summary for 3S9Y

Entry DOI	10.2210/pdb3s9y/pdb
Related	2Q8L 2Q8Z 2QAF 3BAR 3BPW 3MWA 3N34
Descriptor	Orotidine 5'-phosphate decarboxylase, 6-amino-5-fluorouridine 5'-(dihydrogen phosphate), SULFATE ION, ... (7 entities in total)
Functional Keywords	p. falciparum, orotidine 5'-monophosphate decarboxylase, 5-fluoro-6-amino-ump, 5-fluoro-6-azido-ump, decarboxylase, lyase
Biological source	Plasmodium falciparum
Total number of polymer chains	4
Total formula weight	161943.59
Authors	Liu, Y.,Kotra, L.P.,Pai, E.F. (deposition date: 2011-06-02, release date: 2012-04-18, Last modification date: 2023-09-13)
Primary citation	Bello, A.M.,Konforte, D.,Poduch, E.,Furlonger, C.,Wei, L.,Liu, Y.,Lewis, M.,Pai, E.F.,Paige, C.J.,Kotra, L.P. Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. J.Med.Chem., 52:1648-1658, 2009 Cited by PubMed: 19260677 DOI: 10.1021/jm801224t PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation