2Q8Z

Crystal structure of Plasmodium falciparum orotidine 5'-phosphate decarboxylase complexed with 6-amino-UMP

Summary for 2Q8Z

• Entry DOI: 10.2210/pdb2q8z/pdb
• Related: 2Q8L
• Descriptor: Orotidine-monophosphate-decarboxylase, SULFATE ION, 6-AMINOURIDINE 5'-MONOPHOSPHATE, ... (6 entities in total)
• Functional Keywords: plasmodium falciparum, orotidine 5'-phosphate decarboxylase, 6-amino-ump, lyase
• Biological source: Plasmodium falciparum
• Total number of polymer chains: 2
• Total formula weight: 81192.06

Authors

Liu, Y.,Lau, W.,Bello, A.M.,Kotra, L.P.,Hui, R.,Pai, E.F. (deposition date: 2007-06-12, release date: 2008-01-29, Last modification date: 2023-08-30)

• Primary citation: Bello, A.M.,Poduch, E.,Liu, Y.,Wei, L.,Crandall, I.,Wang, X.,Dyanand, C.,Kain, K.C.,Pai, E.F.,Kotra, L.P.; Structure-Activity Relationships of C6-Uridine Derivatives Targeting Plasmodia Orotidine Monophosphate Decarboxylase.; J.Med.Chem., 51:439-448, 2008; PubMed: 18189347; DOI: 10.1021/jm7010673

Experimental method

X-RAY DIFFRACTION (1.8 Å)