2Q8Z
Crystal structure of Plasmodium falciparum orotidine 5'-phosphate decarboxylase complexed with 6-amino-UMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 501 |
| Chain | Residue |
| A | ARG150 |
| A | GLU155 |
| A | ASP179 |
| A | LYS182 |
| A | HOH787 |
| A | HOH847 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 501 |
| Chain | Residue |
| B | GLU180 |
| B | GLU181 |
| B | HOH799 |
| B | LYS147 |
| B | ARG150 |
| B | ASP179 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE NUP A 401 |
| Chain | Residue |
| A | ASP23 |
| A | LYS102 |
| A | ASN104 |
| A | ASP136 |
| A | LYS138 |
| A | THR194 |
| A | THR195 |
| A | PRO264 |
| A | GLN269 |
| A | ASN291 |
| A | GLY293 |
| A | ARG294 |
| A | HOH709 |
| A | HOH725 |
| A | HOH728 |
| A | HOH749 |
| A | HOH750 |
| A | HOH796 |
| B | ASP141 |
| B | ILE142 |
| B | THR145 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE 7PE A 601 |
| Chain | Residue |
| A | ASN299 |
| A | MET308 |
| A | GLN312 |
| site_id | AC5 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE NUP B 401 |
| Chain | Residue |
| A | ASP141 |
| A | ILE142 |
| A | THR145 |
| B | ASP23 |
| B | LYS102 |
| B | ASN104 |
| B | ASP136 |
| B | LYS138 |
| B | THR194 |
| B | THR195 |
| B | PRO264 |
| B | GLN269 |
| B | ASN291 |
| B | GLY293 |
| B | ARG294 |
| B | HOH707 |
| B | HOH726 |
| B | HOH728 |
| B | HOH738 |
| B | HOH754 |
| B | HOH779 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG A 701 |
| Chain | Residue |
| A | TYR185 |
| A | TYR227 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PEG B 701 |
| Chain | Residue |
| B | ALA295 |
| B | ASN299 |
| B | PRO300 |
| B | TYR301 |
| B | ALA305 |
| B | TYR309 |
Functional Information from PROSITE/UniProt
| site_id | PS00156 |
| Number of Residues | 14 |
| Details | OMPDECASE Orotidine 5'-phosphate decarboxylase active site. TIlDmKinDIGnTV |
| Chain | Residue | Details |
| A | THR133-VAL146 |
