3RI1
Crystal structure of the catalytic domain of FGFR2 kinase in complex with ARQ 069
Summary for 3RI1
Entry DOI | 10.2210/pdb3ri1/pdb |
Descriptor | Fibroblast growth factor receptor 2, (6S)-6-phenyl-5,6-dihydrobenzo[h]quinazolin-2-amine, SULFATE ION, ... (4 entities in total) |
Functional Keywords | fgfr1 kinase, fgfr2 kinase, inactive conformation, kinase-inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: P21802 |
Total number of polymer chains | 2 |
Total formula weight | 72941.64 |
Authors | Eathiraj, S.,Palma, R.,Hirschi, M.,Volckova, E.,Nakuci, E.,Castro, J.,Chen, C.R.,Chan, T.C.,France, D.S.,Ashwell, M.A. (deposition date: 2011-04-12, release date: 2011-05-04, Last modification date: 2011-10-19) |
Primary citation | Eathiraj, S.,Palma, R.,Hirschi, M.,Volckova, E.,Nakuci, E.,Castro, J.,Chen, C.R.,Chan, T.C.,France, D.S.,Ashwell, M.A. A novel mode of protein kinase inhibition exploiting hydrophobic motifs of autoinhibited kinases: discovery of ATP-independent inhibitors of fibroblast growth factor receptor. J.Biol.Chem., 286:20677-20687, 2011 Cited by PubMed: 21454610DOI: 10.1074/jbc.M110.213736 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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