3R1N
MK3 kinase bound to Compound 5b
Summary for 3R1N
Entry DOI | 10.2210/pdb3r1n/pdb |
Related | 3R2B 3R2Y 3R30 |
Descriptor | MAP kinase-activated protein kinase 3, 2'-[2-(1,3-benzodioxol-5-yl)pyrimidin-4-yl]-5',6'-dihydrospiro[piperidine-4,7'-pyrrolo[3,2-c]pyridin]-4'(1'H)-one (3 entities in total) |
Functional Keywords | kinase domain with bound inhibitor, kinase domain, phosphotransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : Q16644 |
Total number of polymer chains | 1 |
Total formula weight | 36832.04 |
Authors | Oubrie, A.,Kazemier, B. (deposition date: 2011-03-11, release date: 2011-05-25, Last modification date: 2024-02-21) |
Primary citation | Barf, T.,Kaptein, A.,Wilde, S.,Heijden, R.,Someren, R.,Demont, D.,Schultz-Fademrecht, C.,Versteegh, J.,Zeeland, M.,Seegers, N.,Kazemier, B.,Kar, B.,Hoek, M.,Roos, J.,Klop, H.,Smeets, R.,Hofstra, C.,Hornberg, J.,Oubrie, A. Structure-based lead identification of ATP-competitive MK2 inhibitors. Bioorg.Med.Chem.Lett., 21:3818-3822, 2011 Cited by PubMed: 21565500DOI: 10.1016/j.bmcl.2011.04.018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.09 Å) |
Structure validation
Download full validation report