3QKL

Spirochromane Akt Inhibitors

Summary for 3QKL

Entry DOI	10.2210/pdb3qkl/pdb
Related	3OCB 3QKK 3QKM
Descriptor	RAC-alpha serine/threonine-protein kinase, GSK-3 beta peptide, N-{(2S)-3-[(3S)-8',9'-dihydro-1H,3'H-spiro[piperidine-3,7'-pyrano[3,2-e]indazol]-1-yl]-2-hydroxypropyl}-N-(2-ethoxyethyl)-2,6-dimethylbenzenesulfonamide, ... (4 entities in total)
Functional Keywords	kinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P31749
Total number of polymer chains	2
Total formula weight	41146.91
Authors	Kallan, N.C.,Spencer, K.L.,Blake, J.F.,Xu, R.,Heizer, J.,Bencsik, J.R.,Mitchell, I.S.,Gloor, S.L.,Martinson, M.,Risom, T.,Gross, S.D.,Morales, T.,Vigers, G.P.A.,Brandhuber, B.J.,Skelton, N.J. (deposition date: 2011-02-01, release date: 2011-03-30, Last modification date: 2011-07-13)
Primary citation	Kallan, N.C.,Spencer, K.L.,Blake, J.F.,Xu, R.,Heizer, J.,Bencsik, J.R.,Mitchell, I.S.,Gloor, S.L.,Martinson, M.,Risom, T.,Gross, S.D.,Morales, T.H.,Wu, W.I.,Vigers, G.P.,Brandhuber, B.J.,Skelton, N.J. Discovery and SAR of spirochromane Akt inhibitors. Bioorg.Med.Chem.Lett., 21:2410-2414, 2011 Cited by PubMed: 21392984 DOI: 10.1016/j.bmcl.2011.02.073 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation