3OCB
Akt1 kinase domain with pyrrolopyrimidine inhibitor
Summary for 3OCB
Entry DOI | 10.2210/pdb3ocb/pdb |
Descriptor | v-akt murine thymoma viral oncogene homolog 1 (AKT1), GSK 3 beta peptide, (2S)-2-(4-chlorobenzyl)-3-oxo-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]propan-1-amine, ... (4 entities in total) |
Functional Keywords | serine-threonine kinase, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 81978.16 |
Authors | Morales, T.H.,Vigers, G.P.A.,Brandhuber, B.J. (deposition date: 2010-08-09, release date: 2010-09-15, Last modification date: 2011-07-13) |
Primary citation | Blake, J.F.,Kallan, N.C.,Xiao, D.,Xu, R.,Bencsik, J.R.,Skelton, N.J.,Spencer, K.L.,Mitchell, I.S.,Woessner, R.D.,Gloor, S.L.,Risom, T.,Gross, S.D.,Martinson, M.,Morales, T.H.,Vigers, G.P.,Brandhuber, B.J. Discovery of pyrrolopyrimidine inhibitors of Akt. Bioorg.Med.Chem.Lett., 20:5607-5612, 2010 Cited by PubMed: 20810279DOI: 10.1016/j.bmcl.2010.08.053 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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