3QIO
Crystal Structure of HIV-1 RNase H with engineered E. coli loop and N-hydroxy quinazolinedione inhibitor
Summary for 3QIO
Entry DOI | 10.2210/pdb3qio/pdb |
Related | 3HYF |
Descriptor | Gag-Pol polyprotein,Ribonuclease HI,Gag-Pol polyprotein, MANGANESE (II) ION, SULFATE ION, ... (5 entities in total) |
Functional Keywords | rnase h, hiv-1, inhibitor, nuclease, transferase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Human immunodeficiency virus type 1 group M subtype B (HIV-1) More |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 |
Total number of polymer chains | 1 |
Total formula weight | 17445.71 |
Authors | Lansdon, E.B.,Liu, Q. (deposition date: 2011-01-27, release date: 2011-04-20, Last modification date: 2023-09-13) |
Primary citation | Lansdon, E.B.,Liu, Q.,Leavitt, S.A.,Balakrishnan, M.,Perry, J.K.,Lancaster-Moyer, C.,Kutty, N.,Liu, X.,Squires, N.H.,Watkins, W.J.,Kirschberg, T.A. Structural and Binding Analysis of Pyrimidinol Carboxylic Acid and N-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors. Antimicrob.Agents Chemother., 55:2905-2915, 2011 Cited by PubMed: 21464257DOI: 10.1128/AAC.01594-10 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4011 Å) |
Structure validation
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