3PPY

Crystal structure of the D1596A/N1602A double mutant of an engineered VWF A2 domain (N1493C and C1670S)

Summary for 3PPY

• Entry DOI: 10.2210/pdb3ppy/pdb
• Related: 3GXB 3PPV 3PPW 3PPX
• Descriptor: von Willebrand factor, SODIUM ION (3 entities in total)
• Functional Keywords: von willebrand factor, vwa domain, and calcium, rossmann fold, blood coagulation, cell adhesion, protein unfolding, and adamts13 cleavage, glycosylation
• Biological source: Homo sapiens (human)
• Cellular location: Secreted : P04275
• Total number of polymer chains: 1
• Total formula weight: 21999.78

Authors

Zhou, M.,Dong, X.,Zhong, C.,Ding, J. (deposition date: 2010-11-25, release date: 2011-05-04, Last modification date: 2023-11-01)

• Primary citation: Zhou, M.,Dong, X.,Baldauf, C.,Chen, H.,Zhou, Y.,Springer, T.A.,Luo, X.,Zhong, C.,Grater, F.,Ding, J.; A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13; Blood, 117:4623-4631, 2011; PubMed: 21385852; DOI: 10.1182/blood-2010-11-321596

Experimental method

X-RAY DIFFRACTION (2 Å)