3PPY
Crystal structure of the D1596A/N1602A double mutant of an engineered VWF A2 domain (N1493C and C1670S)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | von Willebrand factor | polymer | 196 | 21976.8 | 1 | UniProt (P04275) Pfam (PF00092) | Homo sapiens (human) | vWF, von Willebrand antigen 2, von Willebrand antigen II |
| 2 | B (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 3 | C (A) | water | water | 18.0 | 157 | Chemie (HOH) |
Sequence modifications
A: 1488 - 1674 (UniProt: P04275)
| PDB | External Database | Details |
|---|---|---|
| Met 1487 | - | expression tag |
| Cys 1493 | Asn 1493 | engineered mutation |
| Ala 1596 | Asp 1596 | engineered mutation |
| Ala 1602 | Asn 1602 | engineered mutation |
| Ser 1670 | Cys 1670 | engineered mutation |
| Leu 1675 | - | expression tag |
| Glu 1676 | - | expression tag |
| His 1677 | - | expression tag |
| His 1678 | - | expression tag |
| His 1679 | - | expression tag |
| His 1680 | - | expression tag |
| His 1681 | - | expression tag |
| His 1682 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 21976.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 23.0 | |
| All* | Total formula weight | 21999.8 |
