3PPY

Crystal structure of the D1596A/N1602A double mutant of an engineered VWF A2 domain (N1493C and C1670S)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	von Willebrand factor	polymer	196	21976.8	1	UniProt (P04275) Pfam (PF00092) In PDB	Homo sapiens (human)	vWF, von Willebrand antigen 2, von Willebrand antigen II
2	A	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
3		water	water		18.0	157	Chemie (HOH)

Sequence modifications

A: 1488 - 1674 (UniProt: P04275)

PDB	External Database	Details
Met 1487	-	expression tag
Cys 1493	Asn 1493	engineered mutation
Ala 1596	Asp 1596	engineered mutation
Ala 1602	Asn 1602	engineered mutation
Ser 1670	Cys 1670	engineered mutation
Leu 1675	-	expression tag
Glu 1676	-	expression tag
His 1677	-	expression tag
His 1678	-	expression tag
His 1679	-	expression tag
His 1680	-	expression tag
His 1681	-	expression tag
His 1682	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	21976.8
Non-Polymers*	Number of molecules	1
	Total formula weight	23.0
All*	Total formula weight	21999.8

*Water molecules are not included.