3O51
Crystal structure of anthranilamide 10 bound to AuroraA
Summary for 3O51
Entry DOI | 10.2210/pdb3o51/pdb |
Related | 3O50 |
Descriptor | cDNA FLJ58295, highly similar to Serine/threonine-protein kinase 6, N-[4-({3-[5-fluoro-2-(methylideneamino)pyrimidin-4-yl]pyridin-2-yl}oxy)phenyl]-2-(phenylamino)benzamide (2 entities in total) |
Functional Keywords | auroraa, kinase domain, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 31541.21 |
Authors | Huang, X. (deposition date: 2010-07-27, release date: 2010-08-18, Last modification date: 2024-02-21) |
Primary citation | Cee, V.J.,Schenkel, L.B.,Hodous, B.L.,Deak, H.L.,Nguyen, H.N.,Olivieri, P.R.,Romero, K.,Bak, A.,Be, X.,Bellon, S.,Bush, T.L.,Cheng, A.C.,Chung, G.,Coats, S.,Eden, P.M.,Hanestad, K.,Gallant, P.L.,Gu, Y.,Huang, X.,Kendall, R.L.,Lin, M.H.,Morrison, M.J.,Patel, V.F.,Radinsky, R.,Rose, P.E.,Ross, S.,Sun, J.R.,Tang, J.,Zhao, H.,Payton, M.,Geuns-Meyer, S.D. Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine aurora kinase inhibitor. J.Med.Chem., 53:6368-6377, 2010 Cited by PubMed: 20684549DOI: 10.1021/jm100394y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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