3O50

Crystal structure of benzamide 9 bound to AuroraA

Summary for 3O50

• Entry DOI: 10.2210/pdb3o50/pdb
• Related: 3O51
• Descriptor: cDNA FLJ58295, highly similar to Serine/threonine-protein kinase 6, N-{3-methyl-4-[(3-pyrimidin-4-ylpyridin-2-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide (3 entities in total)
• Functional Keywords: auroraa, kinase domain, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 62974.22

Authors

Huang, X. (deposition date: 2010-07-27, release date: 2010-08-18, Last modification date: 2024-02-21)

• Primary citation: Cee, V.J.,Schenkel, L.B.,Hodous, B.L.,Deak, H.L.,Nguyen, H.N.,Olivieri, P.R.,Romero, K.,Bak, A.,Be, X.,Bellon, S.,Bush, T.L.,Cheng, A.C.,Chung, G.,Coats, S.,Eden, P.M.,Hanestad, K.,Gallant, P.L.,Gu, Y.,Huang, X.,Kendall, R.L.,Lin, M.H.,Morrison, M.J.,Patel, V.F.,Radinsky, R.,Rose, P.E.,Ross, S.,Sun, J.R.,Tang, J.,Zhao, H.,Payton, M.,Geuns-Meyer, S.D.; Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine aurora kinase inhibitor.; J.Med.Chem., 53:6368-6377, 2010; PubMed: 20684549; DOI: 10.1021/jm100394y

Experimental method

X-RAY DIFFRACTION (2 Å)