3NYA
Crystal structure of the human beta2 adrenergic receptor in complex with the neutral antagonist alprenolol
Summary for 3NYA
Entry DOI | 10.2210/pdb3nya/pdb |
Related | 2RH1 3D4S 3NY8 3NY9 |
Descriptor | Beta-2 adrenergic receptor, Lysozyme, CHOLESTEROL, (2S)-1-[(1-methylethyl)amino]-3-(2-prop-2-en-1-ylphenoxy)propan-2-ol, ... (4 entities in total) |
Functional Keywords | g protein-coupled receptor, lysozyme, fusion, transducer, adrenergic, g-proteins, arrestins, adrenaline, alprenolol, glycosylation, palmitoylation, phosphorylation, membrane protein, hydrolase, structural genomics, psi-biology, gpcr network, gpcr |
Biological source | Homo sapiens More |
Cellular location | Cell membrane ; Multi- pass membrane protein : P07550 |
Total number of polymer chains | 1 |
Total formula weight | 56980.58 |
Authors | Brown, M.A.,Wacker, D.,Fenalti, G.,Katritch, V.,Abagyan, R.,Cherezov, V.,Stevens, R.C.,GPCR Network (GPCR) (deposition date: 2010-07-14, release date: 2010-08-11, Last modification date: 2023-09-06) |
Primary citation | Wacker, D.,Fenalti, G.,Brown, M.A.,Katritch, V.,Abagyan, R.,Cherezov, V.,Stevens, R.C. Conserved Binding Mode of Human beta(2) Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography J.Am.Chem.Soc., 132:11443-11445, 2010 Cited by PubMed: 20669948DOI: 10.1021/ja105108q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.16 Å) |
Structure validation
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