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3NY8

Crystal structure of the human beta2 adrenergic receptor in complex with the inverse agonist ICI 118,551

Summary for 3NY8
Entry DOI10.2210/pdb3ny8/pdb
Related2RH1 3D4S 3NY9 3NYA
DescriptorBeta-2 adrenergic receptor, Lysozyme, CHOLESTEROL, (2S,3S)-1-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]butan-2-ol, ... (7 entities in total)
Functional Keywordsg protein-coupled receptor, lysozyme, fusion, transducer, adrenergic, g-proteins, arrestins, adrenalin, ici 118, 551, glycosylation, palmitoylation, phosphorylation, membrane protein, hydrolase, structural genomics, psi-2, protein structure initiative, accelerated technologies center for gene to 3d structure, atcg3d, gpcr network, gpcr
Biological sourceHomo sapiens
More
Cellular locationCell membrane ; Multi- pass membrane protein : P07550
Total number of polymer chains1
Total formula weight58154.35
Authors
Primary citationWacker, D.,Fenalti, G.,Brown, M.A.,Katritch, V.,Abagyan, R.,Cherezov, V.,Stevens, R.C.
Conserved Binding Mode of Human beta(2) Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography
J.Am.Chem.Soc., 132:11443-11445, 2010
Cited by
PubMed: 20669948
DOI: 10.1021/ja105108q
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.84 Å)
Structure validation

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