3N85

Crystallographic trimer of HER2 extracellular regions in complex with tryptophan-rich antibody fragment

Summary for 3N85

• Entry DOI: 10.2210/pdb3n85/pdb
• Related: 1IVO 1MOX 1N8Z 1S78 1ZA3 3I2T
• Descriptor: Receptor tyrosine-protein kinase erbB-2, Fab37 Light Chain, Fab37 Heavy Chain, ... (7 entities in total)
• Functional Keywords: her2, erbb2, trp/ser library, phage display, transferase-immune system complex, transferase/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 119434.93

Authors

Eigenbrot, C. (deposition date: 2010-05-27, release date: 2010-07-28, Last modification date: 2023-09-06)

• Primary citation: Fisher, R.D.,Ultsch, M.,Lingel, A.,Schaefer, G.,Shao, L.,Birtalan, S.,Sidhu, S.S.,Eigenbrot, C.; Structure of the complex between HER2 and an antibody paratope formed by side chains from tryptophan and serine.; J.Mol.Biol., 402:217-229, 2010; PubMed: 20654626; DOI: 10.1016/j.jmb.2010.07.027

Experimental method

X-RAY DIFFRACTION (3.2 Å)