3N56
Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human B-type natriuretic peptide (BNP)
Summary for 3N56
Entry DOI | 10.2210/pdb3n56/pdb |
Related | 1YK1 2G47 2WBY 3CWW 3E4Z 3H44 3N57 |
Descriptor | Insulin-degrading enzyme, Natriuretic peptides B, ZINC ION, ... (5 entities in total) |
Functional Keywords | insulysin, insulinase, a-beta degrading enzyme, cryptidase, hydrolase, hormone, disease mutation, diabetes mellitus, insulin, cardiac, secreted, protease, disulfide bond, metalloprotease, human insulin-degradng enzyme, metal-binding, natriuretic peptide, natriuretic factor, cardiovascular regulation, hydrolase-hormone complex, hydrolase/hormone |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P14735 Secreted: P16860 |
Total number of polymer chains | 4 |
Total formula weight | 236376.42 |
Authors | Funke, T.,Guo, Q.,Tang, W.-J. (deposition date: 2010-05-24, release date: 2010-11-17, Last modification date: 2023-09-06) |
Primary citation | Ralat, L.A.,Funke, T.,Ren, M.,Guo, Q.,Dickey, D.M.,Potter, L.R.,Tang, W.-J. Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human B-type natriuretic peptide (BNP) To be Published, |
Experimental method | X-RAY DIFFRACTION (3.102 Å) |
Structure validation
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