2G47
Crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-40)
Summary for 2G47
Entry DOI | 10.2210/pdb2g47/pdb |
Related | 2G48 2G49 2G54 2G56 |
Descriptor | Insulin-degrading enzyme, amyloid protein beta A4, 1,4-DIETHYLENE DIOXIDE, ... (4 entities in total) |
Functional Keywords | protein-peptide complex, hydrolase |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P14735 |
Total number of polymer chains | 4 |
Total formula weight | 238278.20 |
Authors | Shen, Y.,Tang, W.-J. (deposition date: 2006-02-21, release date: 2006-10-24, Last modification date: 2024-02-14) |
Primary citation | Shen, Y.,Joachimiak, A.,Rosner, M.R.,Tang, W.J. Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism. Nature, 443:870-874, 2006 Cited by PubMed: 17051221DOI: 10.1038/nature05143 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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