3MV5

Crystal structure of Akt-1-inhibitor complexes

Summary for 3MV5

Entry DOI	10.2210/pdb3mv5/pdb
Related	3CQU 3CQW 3MVH 3MVJ
Descriptor	v-akt murine thymoma viral oncogene homolog 1 (AKT1), GSK3-beta peptide, MANGANESE (II) ION, ... (5 entities in total)
Functional Keywords	kinase inhibitor, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	41003.52
Authors	Pandit, J. (deposition date: 2010-05-03, release date: 2010-06-02, Last modification date: 2021-10-06)
Primary citation	Freeman-Cook, K.D.,Autry, C.,Borzillo, G.,Gordon, D.,Barbacci-Tobin, E.,Bernardo, V.,Briere, D.,Clark, T.,Corbett, M.,Jakubczak, J.,Kakar, S.,Knauth, E.,Lippa, B.,Luzzio, M.J.,Mansour, M.,Martinelli, G.,Marx, M.,Nelson, K.,Pandit, J.,Rajamohan, F.,Robinson, S.,Subramanyam, C.,Wei, L.,Wythes, M.,Morris, J. Design of selective, ATP-competitive inhibitors of Akt. J.Med.Chem., 53:4615-4622, 2010 Cited by PubMed: 20481595 DOI: 10.1021/jm1003842 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.47 Å)

Structure validation