3MP3

Crystal Structure of Human Lyase in complex with inhibitor HG-CoA

Summary for 3MP3

Entry DOI	10.2210/pdb3mp3/pdb
Related	2cw6 3MP4 3MP5
Descriptor	Hydroxymethylglutaryl-CoA lyase, 3-HYDROXYPENTANEDIOIC ACID, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	ketogenic enzyme, human hmg-coa lyase, 3-hydroxylglutaryl-coa, lyase
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion matrix: P35914
Total number of polymer chains	6
Total formula weight	190657.34
Authors	Fu, Z.,Runquist, J.A.,Montgomery, C.,Miziorko, H.M.,Kim, J.-J.P. (deposition date: 2010-04-24, release date: 2010-06-16, Last modification date: 2023-09-06)
Primary citation	Fu, Z.,Runquist, J.A.,Montgomery, C.,Miziorko, H.M.,Kim, J.J. Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes. J.Biol.Chem., 285:26341-26349, 2010 Cited by PubMed: 20558737 DOI: 10.1074/jbc.M110.139931 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation