2CW6
Crystal Structure of Human HMG-CoA Lyase: Insights into Catalysis and the Molecular Basis for Hydroxymethylglutaric Aciduria
Summary for 2CW6
Entry DOI | 10.2210/pdb2cw6/pdb |
Descriptor | Hydroxymethylglutaryl-CoA lyase, mitochondrial, MAGNESIUM ION, 3-HYDROXYPENTANEDIOIC ACID, ... (4 entities in total) |
Functional Keywords | hmg-coa lyase, ketogenic enzyme, lyase |
Biological source | Homo sapiens (human) |
Cellular location | Mitochondrion matrix: P35914 |
Total number of polymer chains | 6 |
Total formula weight | 189759.71 |
Authors | Fu, Z.,Runquist, J.A.,Hunt, J.F.,Miziorko, H.M.,Kim, J.-J.P. (deposition date: 2005-06-17, release date: 2005-12-06, Last modification date: 2024-03-13) |
Primary citation | Fu, Z.,Runquist, J.A.,Forouhar, F.,Hussain, M.,Hunt, J.F.,Miziorko, H.M.,Kim, J.-J.P. Crystal structure of human 3-hydroxy-3-methylglutaryl-CoA Lyase: insights into catalysis and the molecular basis for hydroxymethylglutaric aciduria J.Biol.Chem., 281:7526-7532, 2006 Cited by PubMed: 16330550DOI: 10.1074/jbc.M506880200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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